Hi all,compared to SBS，SBL has a much shorter read length（SOLiDv4‘s 50 to Hiseq 2000’s 1000）.Which causes this disadvange?
-
-
the HiSeq 2000 has max read length 100bp (paired end: 2x100bp)
the SOLiD 5500xl has max read length 75bp (paired end: 2x60bp)
as you said, the difference lies within the method (SBS vs. SBL). at the moment ABi can only ensure 12 or so ligation cycles without obtaining bad read quality at the end. but they most likely are working on the chemistry to further improve this.
-
Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?
Liquid biopsies can detect tumor-derived material circulating in the bloodstream, providing a way to study treatment response, detect emerging resistance, and discover new biomarkers. Circulating...10-14-2026, 09:55 AM
Comment