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How many missense/nonsense per coding Mb?

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  • How many missense/nonsense per coding Mb?

    what is average number of missense/nonsense per Mb of coding DNA? I found 500 variants/Mb but that includes also synonimous.

  • #2
    Please don't post the same question in multiple forums. That may not necessarily increase your chances of getting an answer.

    As for your question: That is going to be dependent on the genome etc. I don't think there can be a single answer.
    Last edited by GenoMax; 01-08-2016, 10:24 AM.

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    • #3
      Originally posted by vasvale View Post
      what is average number of missense/nonsense per Mb of coding DNA? I found 500 variants/Mb but that includes also synonimous.
      Yes, that sounds about right from the known human SNPs. That said, GenoMax is correct in that it will depend on the genome.

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      • #4
        I am looking for average in human genomes, could not find info on exomes papers

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        • #5
          For the human genome I use 1/100 in the non-coding regions and 1/1000 in the coding regions. Per individual of course. This tends to be roughly true. But it will differ between non coding regions and between genes.

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