Tweet
what is average number of missense/nonsense per Mb of coding DNA? I found 500 variants/Mb but that includes also synonimous.
-
-
Please don't post the same question in multiple forums. That may not necessarily increase your chances of getting an answer.
As for your question: That is going to be dependent on the genome etc. I don't think there can be a single answer.Last edited by GenoMax; 01-08-2016, 10:24 AM. -
Yes, that sounds about right from the known human SNPs. That said, GenoMax is correct in that it will depend on the genome.Originally posted by vasvale View PostComment
-
I am looking for average in human genomes, could not find info on exomes papersComment
-
For the human genome I use 1/100 in the non-coding regions and 1/1000 in the coding regions. Per individual of course. This tends to be roughly true. But it will differ between non coding regions and between genes.Comment
-
During the COVID-19 pandemic, scientists observed that while some individuals experienced severe illness when infected with SARS-CoV-2, others were barely affected. These disparities left researchers and clinicians wondering what causes the wide variations in response to viral infections and what role genetics plays.
Jean-Laurent Casanova, M.D., Ph.D., Professor at Rockefeller University, is a leading expert in this crossover between genetics and infectious...09-09-2024, 10:59 AM -
The first FDA-approved CRISPR-based therapy marked the transition of therapeutic gene editing from a dream to reality1. CRISPR technologies have streamlined gene editing, and CRISPR screens have become an important approach for identifying genes involved in disease processes2. This technique introduces targeted mutations across numerous genes, enabling large-scale identification of gene functions, interactions, and pathways3. Identifying the full range...08-27-2024, 04:44 AM
Comment