I would like to convert SNP positions to Amino Acid positions in the current UniProt database. My goal is to determine if SNPS are in specific annotated domains (eg phosphorylation sites, transmembrane domains, DNA binding domains, etc). I have used the web based version of PolyPhen2 but that uses an older version of the uniprot DB than the one I am using so there were some discrepancies (~3 percent of AAs didn't match up). And I am having difficulty installing a local version of PolyPhen2. It seems likely to me that there is other software out there to do this. Any suggestions?
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The immune system’s power comes from its genetic diversity, allowing myriad threats to be neutralized through first recognizing foreign antigens. That diversity is also what makes the immune system so difficult to study. Recent advances in sequencing technology and computational biology, however, are giving researchers new tools to understand immune responses and immune-related diseases in greater detail.
This convergence of genetics, immunology, and computation...09-01-2026, 05:41 AM