I would like to convert SNP positions to Amino Acid positions in the current UniProt database. My goal is to determine if SNPS are in specific annotated domains (eg phosphorylation sites, transmembrane domains, DNA binding domains, etc). I have used the web based version of PolyPhen2 but that uses an older version of the uniprot DB than the one I am using so there were some discrepancies (~3 percent of AAs didn't match up). And I am having difficulty installing a local version of PolyPhen2. It seems likely to me that there is other software out there to do this. Any suggestions?
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Tumors contain complex mixtures of cell populations that evolve in response to treatment and host-specific factors. Tissue biopsies provide only static snapshots of a tumor’s state. But what if we could follow that evolution over time using a minimally invasive technique?
Liquid biopsies can detect tumor-derived material circulating in the bloodstream, providing a way to study treatment response, detect emerging resistance, and discover new biomarkers. Circulating...10-14-2026, 09:55 AM -
Researchers using sequencing and genomics tools often have to make trade-offs. They can choose between speed or scale, short reads or long-range information, or targeted panels or a view of the whole transcriptome. New technologies that have been released this year are built to address those tough choices.
We asked six companies the same four questions to learn about their latest products. The new technologies bring a lot to the table, including rethinking sequencing...