I would like to convert SNP positions to Amino Acid positions in the current UniProt database. My goal is to determine if SNPS are in specific annotated domains (eg phosphorylation sites, transmembrane domains, DNA binding domains, etc). I have used the web based version of PolyPhen2 but that uses an older version of the uniprot DB than the one I am using so there were some discrepancies (~3 percent of AAs didn't match up). And I am having difficulty installing a local version of PolyPhen2. It seems likely to me that there is other software out there to do this. Any suggestions?
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by seqadmin
The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist...-
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04-22-2024, 07:01 AM -
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Proteins are often described as the workhorses of the cell, and identifying their sequences is key to understanding their role in biological processes and disease. Currently, the most common technique used to determine protein sequences is mass spectrometry. While still a valuable tool, mass spectrometry faces several limitations and requires a highly experienced scientist familiar with the equipment to operate it. Additionally, other proteomic methods, like affinity assays, are constrained...-
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04-04-2024, 04:25 PM -
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