I am trying to find the most significant altered genes and I was thinking of using only 1 tool for significance test which is MutSigCV instead of MutSigCV for mutation data and GISTIC for CNV data. I know that MutSigCV works with short indels but can I merge my CNV segmented data in the MAF file (Divide each long CNV into regions) and input them to MutSigCV or this wouldn't work? Can MutSigCV work with long insertions or deletions? What is the maximum indel length that MutSigCV can operate on?
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The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist...-
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Proteins are often described as the workhorses of the cell, and identifying their sequences is key to understanding their role in biological processes and disease. Currently, the most common technique used to determine protein sequences is mass spectrometry. While still a valuable tool, mass spectrometry faces several limitations and requires a highly experienced scientist familiar with the equipment to operate it. Additionally, other proteomic methods, like affinity assays, are constrained...-
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04-04-2024, 04:25 PM -
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