Hi,
I have been trying to make a ChIP-Seq library using TruSeq Adapters. Even though the DNA profile looks good on the bioanalyzer, I'm not able to get any product after library enrichment.
I've tried other samples, which were low in DNA amount and were not the cleanest, but they still gave me a good amount of library.
Any thoughts what could be the problem? My guess was something is inhibiting the adapter ligation so I cleaned the sample with 1.8X AMPure. But still the same results.
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