Revio from Pacific Biosciences: Latest Sequencing Technologies—Part 3

Pacific Biosciences (PacBio) revealed two new sequencers during this year’s American Society of Human Genetics meeting. The first instrument, Revio, which will be covered in this article, is a significant upgrade from their previous Sequel II device. It has lower costs, shorter run times, more SMRT Cells and zero-mode waveguides (ZMW), and significantly higher output compared to PacBio’s other sequencers.

Read type and length
As a part of PacBio’s long-read sequencing systems,...

There has been a flurry of activity among next-gen sequencing companies this year with a number of new sequencers being announced. In October, Oxford Nanopore Technologies (ONT) announced the release of their new device, the PromethION 2 (P2) Solo sequencer. The P2 Solo is a small, high-yield sequencer with considerably lower starting costs compared to some of its competitors; the starter pack for ONT’s latest device is priced around $10,455. Despite its small size, the P2 Solo stands as a valuable...

In the Fall of 2022 Illumina announced their newest pair of flagship sequencers: the NovaSeq X and the NovaSeq X Plus. Their development was part of Illumina’s pursuit of lowering the cost of sequencing by dropping the price to approximately $200 per genome. The major differences between Illumina’s previous top sequencer (the NovaSeq 6000) and the NovaSeq X and X Plus are that the new devices have more affordable and updated reagents, faster run times, and the ability to process data directly...